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Category - Anxiety Support

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HPA Adapt® (replaces Adren-Plus)

HPA Adapt® (replaces Adren-Plus)

"When physical and/or mental stress occur frequently, the body's ability to optimally respond and restore homeostasis may be affected. This may, in turn, influence mood, cognition, and energy levels.

HPA Adapt is a formulation of five powerful, yet non-stimulating adaptogens shown to support a healthy stress response via the hypothalamic-pituitary-adrenal axis, or HPA axis, which is the central part of the stress response system. It involves a complex set of interactions and feedback loops between the hypothalamus, the pituitary, and the adrenal glands.

The HPA axis also plays a role in the regulation of other systems of the body, including the gastrointestinal, neurological, and immune systems. Therefore, supporting optimal HPA axis function is important to maintaining overall health and wellness. Published human and animal research suggests that these ingredients help promote a healthy response to stressors while reducing stress-related fatigue and mental tension.

These ingredients are:

  • Ashwagandha root and leaf: is an adaptogenic herb historically used in Ayurveda to enhance well-being, support restful sleep, and reduce occasional anxiety.

    A double-blind, placebo-controlled clinical trial (N =39) evaluated the adaptogenic effects of ashwagandha. Compared to placebo, the extract exerted an anti-fatigue effect that increased mental performance, particularly the ability to concentrate, and decreased cortisol response to stress in people with burnout.

  • Eleuthero root: is an adaptogenic herb that helps reduce fatigue, supports attention and cognition,and helps the body cope during periods of stress.

    Animal research has shown that eleuthero supports healthy cortisol production under stress, though this has not yet been demonstrated in human clinical trials.

  • Holy Basil leaf: A member of the mint family, holy basil enhances the body's natural response to physical and emotional stress.

    Compounds isolated from the herb's leaves were shown to normalize plasma cortisol levels in an animal model.

    Another animal study found that extracts of holy basil decreased serum concentrations of cortisol.

    A clinical trial with 35 subjects demonstrated a decrease in stress and occasional anxiety after 60 days of supplementation with holy basil.

    The participants also showed improved attention and an increased ability to adapt to change.

  • Maca root: Preliminary human research suggests that maca may have a positive influence on mood, feelings of occasional anxiety, and libido.

    Although it has not been demonstrated in human clinical studies, animal research has also documented a positive effect of maca on cognitive function and occasional fatigue.

  • Rhodiola root: Various extracts of Rhodiola have been shown in human clinical studies to reduce fatigue, while improving mood, attention, and cognitive function, particularly during times of stress.

    Possible mechanism of actions include interaction with the HPA-axis, protein kinases p-JNK, nitric oxide, and defense mechanism proteins.

    A systematic review of 11 randomized clinical trials concluded that rhodiola may have beneficial effects on physical and mental performance.

    Another preliminary human study suggests that rhodiola supports the body?s response to physical exercise and may improve recovery."


Directions: Take 2 to 4 capsules daily on an empty stomach or as recommended by your healthcare professional.

Other Ingredients: vegetable capsule (modified cellulose), ascorbyl palmitate and silicon dioxide.

Wheat Free, Dairy/ Milk Free, Gluten Free, Vegetarian, Soy Free, Yeast Free, Sugar Free, Preservative Free, Vegan, Salt Free, Free of Artificial Colors/Flavors, Egg Free, Shellfish Free


* These statements have not been evaluated by the U.S.Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease

HPA Adapt® (replaces Adren-Plus) 120 Vegcaps $ 33.60

HPA Adapt® (replaces Adren-Plus) 120 Vegcaps
Element Amount %Daily Allowance% Serving Size
Rhodiola (Rhodiola rosea) Root Extract standardized to contain 3% rosavins and 1% salidroside

Ashwagandha (Withania somnifera)(Sensoril® brand) Root and Leaf Extract

Eleuthero (Eleutherococcus senticosus) Root Extract

Holy Basil (Ocimum sanctum) Leaf Extract standardized to contain 2.5% triterpenoic acids including ursolic and oleanolic acids

MacaPure® brand Maca (Lepidium meyenii)

Root Extract standardized to contain 0.6% macaenes and macamides




150 mg

4 vcaps

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