Catalog                      Follow us on , and
To keep the body in good health is a duty... otherwise we shall not be able to keep our mind strong and clear.
Please come "LIKE", "Friend" & interact with us on  Facebook. Don't be shy.  Let us hear from you. Join us on Twitter and check out our Blogs. Please Share us with your friends.
The functions  of and research on Co-Q10 could fill books, so this is only an overview. Co-Q10 is an extraordinary vitamin-like substance found in every cell in your body.  The chemical name is ubiquinone because it is an ubiquitous quinone.  We depend upon it for life.  It  affects the functions of your every cell, where it is essential for multiple life sustaining processes.
Yet, many drugs deplete this vital nutrient.  If you or a loved one are taking one or more of these drugs, you  need to know and you need to add supplemental Co-Q10. The risk of depletion of Co-Q10 is not made clear in the drug info inserts and you are not advised to replace the lost Co-Q10 while you are using the drug. This practice needs to stop. Don’t blame your Dr, because the drug/Co-Q10 issue is not common knowledge, except for the statins. Any Dr who prescribes a statin  should  tell you to supplement Co-Q10.
Be sure to see the list of culprit drugs at the end of this newsletter .
 Do not stop a prescription medicine without discussing options with your doctor.
Though always working in our bodies, Co-Q10 was only first isolated and described by Dr Frederick Crane in 1957.  Dr Peter Marshall won the 1978 Nobel Prize in Chemistry for his discoveries of the mechanisms of energy transfer in the body, part of which involved the role of Co-Q10. In 1974 the Japanese incorporated it as a prescription item into their treatment for congestive heart failure & other heart disorders. Life Extension Foundation introduced Co-Q10 to the U.S. in 1983. It later became widely available as an OTC nutrient supplement.
Co-Q10 has and is still being extensively studied and is now the 3rd most sold dietary ingredient in the U.S. after the Omega-3’s and multivitamins.
Some of the research clinical trials using CoQ10 as adjunctive therapy involve myalgias & myopathies, statin induced myopathies, myopathic encephalopathies (ME), muscular dystrophy, Mitochondrial Disease, fatigue syndromes, depression, Parkinson’s Disease, Friedrich’s Ataxia, Amyotrophic Lateral Sclerosis, other neurodegenerative diseases, cardiomyopathy, heart failure, heart protection during heart surgery, heart arrhythmia, angina, mitral valve prolapse, heart protection for those on the anthracycline chemotherapeutic agents, hypertension, protection in stroke, LDL cholesterol, blood vessel dilation, migraine, cyclic vomiting syndrome, asthma, age-related macular degeneration, decreased sperm count & motility, chronic kidney failure, breast & other cancers, myelodysplastic syndrome, post surgical melanoma, chronic gum disease, immune function, AIDS, aging, and skin health.
When we are under 30 years old, our body makes about 500 mg of CoQ10 daily. This  is needed to maintain the general body pool of about 2000 mg. By age 65 most people have 50-60% less CoQ10 in their body, the decline of which may be among the myriad of factors contributing to the aging process. We also get about 10 mg of CoQ10 daily from our diet, with  the most coming from fish, muscle meat, liver, kidney, nuts, soy & spinach.
In the miraculous functioning of the body we make our own CoQ10 from other “precursor” nutrients which we convert to CoQ10. Proper functioning of this process depends upon adequate amounts of all the precursors being present & the conversion processes working correctly. It all begins with my old favorites, the amino acids tyrosine & phenylalanine (which are the basis for my book on the natural treatment of depression) and have numerous critical functions in the body. So no surprise that here again these amino acids are so important. These amino acids begin to transform to CoQ10 in the presence of the pyridoxal-5-phosphate form of vitamin B6 (another old favorite). The vitamins B2, B3, B5, Folic acid, vitamin C, and several trace mineral elements must also be present. So you see for proper CoQ10 production we need to be well nourished  enough to have sufficient precursors. Altogether there are 17 steps in the bio-synthesis of this remarkable vitamin-like fat soluble substance found in higher concentrations in high energy areas such as the heart, brain, liver, muscles, pancreas, immune cells, gums, stomach lining, but still in every cell.
CoQ10 primarily modulates disorders related to suboptimal cellular energy metabolism & oxidative injury. My opinion is this could almost relate to every disease state, as most diseases eventuate in a disruption of these primary processes.
Besides certain drugs, other factors leading to depletion of CoQ10 are:
  • Aging
  • Poor diet/ malnutrition
  • Poor digestion and absorption
  • Obesity
  • Excessive exertion
  • Health conditions which increase the body’s energy needs such as hyperthyroidism, AIDS, cancer, acute shock.
CoQ10 is in all cell membranes (membranes separating the cells from the outside environment & controlling what moves in & out of the cells), and in lipoproteins (particles made of fats & proteins that allow the transport of fats through the blood).
Now to the daunting task of "simply" explaining what Co Q10 does:
It helps create the chemical energy (ATP, the body’s main energy storage molecules) for the metabolism or functioning of every cell in your body. The highest concentrations are found in the body areas requiring the most energy. This process is called oxidative phosphorylation , whereby proteins, carbohydrates, and essential fatty acids are broken down to produce energy in the energy factory of the cell called mitochondria.
This creation of energy has the side effect of forming unwanted combustion by-products (free radicals, oxidative or peroxidative by products). Co-Q10 then  helps clean up these noxious molecules with its powerful anti-oxidant actions (neutralizes these highly reactive chemical oxygen &/or nitrogen containing by products which would otherwise react with surrounding molecules to create damaging changes). It exerts these effects in the membrane and DNA of every cell.
These antioxidant effects help modulate the aging process.  A theory of aging is that a lifetime of free radical production gradually causes damage to cellular components such as decreasing the ability to produce the energy storing ATP, mitochondrial mutations which disable the energy processing capacity of the mitochondria, and oxidative damage to DNA.
It plays a role in transporting proteins across the cell membrane to maintain optimal pH balance.
It is a powerful antioxidant in lipoproteins . Co-Q10 & alpha lipoic acid work to protect the lipids in all cell membranes & mitochondrial membranes.  Alpha lipoic acid also helps to recycle/regenerate Co-Q10.
It works synergistically with Vitamin E in its antioxidant functions and helps to conserve vitamin C and E.
It works with the garbage collecting lysosomes to clean up & digest cellular debris. 
It modulates prostaglandins to decrease inflammation
Inhibits intracellular phospholipases (inflammatory chemicals) found in neurological disorders associated with inflammation & oxidative stress such as Alzheimer’s disease, spinal cord injury, decreased blood flow injury.  These are neuroprotective effects.  High doses up to 1200 mg /d have been found to slow the progression of Parkinson's Disease.
It is a calcium channel & membrane stabilizer ( balancing of muscle contraction/relaxation)
Preserves heart muscle Na, K-ATPase (sodium, potassium, adenosine triphosphate) an enzyme performing the active transport of Na & K across the cell membrane to allow muscle contraction and relaxation.
Co-Q10 is highly concentrated in the heart muscle.  Congestive heart failure is strongly correlated with low blood & tissue levels of Co-Q10.  This Co-Q10 deficiency may well be an etiological factor in some types of heart muscle dysfunction.  Multiple studies support that Co-Q10 significantly improves heart muscle function especially diastolic dysfunction (which occurs when the heart muscle stiffens interfering with its ability to pump blood).
This is not an exhaustive list of the functions of CoQ10 , but gives an idea of its importance & variability in function.
Most of the information presented here is obtained from the book Drug-Induced Nutrient Depletion Handbook which is a good book to consult if you are taking medications. As previously mentioned we have our own Co-Q10 manufacturing process in our body and very little of the amount needed is obtained directly from food. But the precursors needed for us to make Co-Q10 are from food. When drugs interfere they are blocking
Here is a list of the prescription drugs that deplete CoQ10 levels.
HMG-CoA Reductase Inhibitors (Statins)
  • Atorvastatin (Lipitor)
  • Cerivastatin (Baycol, Lipobay)
  • Fluvastatin (Lescol, Canef, Vastin)
  • Lovastatin ((Mevacor, Altocor)
  • Pravastatin (Pravachol, Selektine)
  • Simvastatin (Zocor)
Cholesterol-Lowering Medications:
  • Fibric Acid Derivatives
  • Gemfibrozil (Lopid)
Cardiovascular Medications:
  • Alpha2-Adrenergic agonists
  • Clonidine(Catapres)
Calcium Channel Blocking Agents
  • Amlodipine besylate (Norvasc)
  • Bepridil( Bepadin  Vascor)
  • Diltiazem (Cardizem, Cardizem SR, Cardizem CD, Dilacor XR)
  • Felodipine ( Plendi)
  • Funarizine ( Sibelium0
  • Isradipine (DynaCirc)
  • Nicardipine (Cardene)
  • Nifedipine (Adalat, Procardia, Pro cardia XL)
  • Nimodipine ( Nimotop)
  • Verapamil (Calan, Calan SR, Isoptin, IsoptinSR)
  • Acebutolol (Sectral, Prent)
  • Aldomet (Methyldopa)
  • Atenolol (Tenormin)
  • Betaxolol (Betoptic, Betoptic S, Lokren, Kerlone)
  • Bisoprolol (Zebeta)
  • Carteolol (Cartrol, Ocupress, Teoptic, Arteolol, Arteoptic, Calte, Cartéabak, Carteol, Cartéol, Cartrol, Elebloc, Endak, Glauteolol, Mikelan, Poenglaucol, Singlauc)
  • Celiprolol (Cardem, Selectol, Celipres, Celipro, Celol, Cordiax, Dilanorm, Selectol)
  • Esmolol (Brevibioc)
  • Labetalol (Normodyne, Trandate)
  • Levobetaxolol (Betaxon)
  • Levobunolol (Betagan)
  • Metipranolol (OptiPranolol, Betanol, Disorat, Trimepranol)
  • Metoprolol (Lopressor, Toprol XL)
  • Nadolol (Corgard, Anabet, Solgol, Corzide, Alti-Nadolol, Apo-Nadol, Novo-Nadolol )
  • Penbutolol (Levatol, Levatolol, Lobeta, Paginol, Hostabloc, Betapressin)
  • Pindolol Visken, Betapindol, Blockin L, Blocklin L, Calvisken, Cardilate, Decreten, Durapindol, Glauco-Visken, Pectobloc, Pinbetol, Prindolol, Pynastin)
  • Propranolol (Inderal)
  • Sotalol (Betapace)
  • Timolol (Timolol)
  •  Hydralazine (Apresoline)
  • Benzthiazide (Aquatag, Dihydrex, Diucen, Edemax, Exna, Foven)
  • Chlorothiazide (Diuril)
  • Diucardin (Hydroflumethiazide),
  • Hydrochlorothiazide (Dyazide)
  • Hydromox (Quinethazone)
  • Indapamide (Lozol)
  • Methyclothiazide (Aquatensen, Enduron)
  • Metolazone (Mykrox, Zaroxolyn)
  • Renese (Polythiazide)
  • Thiazide Diuretics
  • Trichlormethiazide (Achletin, Diu-Hydrin and Triflumen)
Antidiabetic Medications:
  • Acetohexamide (Dymelor)
  • Chlorpropamide (Diabinese)
  • Glimepiride (Amaryl
  • Glipizide (Glucotol)
  • Glyburide (Micronase)
  • Sulfonylureas (Glimepiride, Glyburide, and Tolazamide)
  • Tolazamide (Tolinase),
  • Tolbutamide 
 Antidepressant Medications:
  • Amitriptyline (Elavil)
  • Amoxapine (Asendin)
  • Clomipramine (Anafranil)
  • Desipramine (Norpramin, Pertofane)
  • Doxepin (Sinequan)
  • Doxorubicin (Adriamycin)
  • Imipramine(Tofranil)
  • Norpramin
  • Nortriptyline(Aventil, Pamelor)
  • Protriptyline(Vivactil)
  • Trimipramine (Surmontil, Rhotrimine, Stangyl)
 Psychotherapeutic Medications-Major Tranquilizers:
  • Apresoline (Hydralazine)
  • Phenothiazine Derivatives
  • Chlorpromazine (Thorazine)
  • Fluphenazine (Permitil. Prolixin)
  • Haloperidol (Haldol)
  • Mesoridazine (Serentil)
  • Perphenazine (Trilafon)
  • Prochlorperazine (Compazine, Stemzine, Buccastem, Stemetil, Phenotil)
  • Promazine (Sparine)
  • Thioridazine (Mellaril)Thiothixene (Navane)
  • Torecan (Thiethylperazine)
  • Trifluoperazine (Stelazine)
Co-Enzyme Q10 is available in 2 forms as a supplement, as ubiquinol & ubiquinone.  The ubiquinol form has only been available since 2006 but is the preferred form, especially if you are at high risk for deficiency or already have a condition which could be helped by Co-Q10.  The ubiquinol form is preferred because it is more bioavailable and produces 4-8 times higher blood levels than the ubiquinone, yet is only about 10% more expensive.
Co-Q10 absorbs better with fats, so needs to be taken with meals. Dosage range is from 30-50mg to 1200 mg daily depending upon the reason for taking.  But keep in mind the body produces 500 mg daily at optimal age & functioning.  About half of that production is lost by 60 years old, so to maintain the same level would need 200-300 mg/d.
If you want to know what your Co-Q10 levels are, you can ask your Dr to order a test or you can order your own test from Life Extension.  However I generally order the 28 nutrient test from Spectra Cell Lab because it measures cellular functions dependent upon steady states of a nutrient over time.
Co-enzyme Q10 is safe and no toxicity or adverse reactions have been reported.  There are conflicting claims that it may interfere with bllod thinner (Warfarin) meds.
I have had no patients report any side effects with CoQ10 but the literature reports rare incidences of stomach upset, headache, diarrhea.

PRISCILLA SLAGLE, M.D. or Cathy Jones, Assisitant
Phone: 1 (760) 322-7797
Fax: 760-322-7608
In this Issue:

Let Congress Know What You Want
Some of our Congress  are  aware of important needed health legislation. They have introduced a bill called the Free Speech About Science Bill (HR 1364).  But they need your help. Urge your representative to vote for this bill. Go here to send your message of support.  This will allow manufacturers of dietary supplements & health foods to:
--Cite scientific legitimate research
--Clearly define the types of research which may be referenced
--Ensure such a reference will not convert the food or supplement into being declared a new drug (and therefore illegal)
--Retain the FDA and FTC authority to pursue fraudulent & misleading statements.
If a nutrient substance is essential for certain life processes, it makes common sense that a deficiency would impair those processes & create symptoms of varying degrees depending upon the severity of the deficiency.  When those symptoms become more severe, they can result in actual disease states, such as a severe vitamin B1 deficiency causing congestive heart failure.
Yet the FDA & FTC, in all their wisdom, does not allow you to be adequately informed of all the info that is available so you can intelligently supplement in a balanced fashion, should you decide to do so.
Numerous reputable capable physicians have been muffled by the restrictions on what you can be told to help your health.  I have protested this is a violation of freedom of speech & have been told such freedom of speech does not exist if you produce or sell an item.
The wisest thing the government could do, now that they have taken over health care, is to promote education about the use of nutritional supplements.  This could be the greatest way to cut overall health care costs.  Let people learn and do as much as they can to stay healthy.  But---this involves common sense.

Introducing New Products at The Way Up
In our continuing effort to bring you a wide range of Alternative Health Supplements, we are pleased to announce 7 new products have been added to our already extensive catalog.
They are:
Arnicare Gel a homeopathic gel that:
  • Relieves muscle aches & stiffness, due to minor injuries, overexertion, falls, and blows.
  • Reducing discoloration from bruising
  • Relieving pain & swelling
  • Useful for everyday pain relief
  • Great for massages
Mito-Fuel a vegetarian, gluten free great tasting orange flavored powder that supports:
  • Mitochondrial function
  • Cellular function
  • Energy through the production and recycling of ATP
  • Exercise tolerance
  • Cardiovascular output
  • Muscle strength and recovery
  • Oxygen utilization and physical stamina
  • Athletic performance and endurance
Stabilium 200  a Great Blue Fish Extract used for centuries to support the body through both mental & physical stress.
It is also effective in:
  • Reducing stress levels before significantly stressful events
  • Augmenting memory
  • Eliminating fatigue
  • Improve cognitive processes
  • Supporting healthy sleep patterns
Traumeel is a 1st line treatment for patients of all ages with acute musculoskeletal injury and pain with proven efficacy and better tolerability than NSAIDS (Nonsteroidal Anti Inflammatory Drugs).
The natural ingredients in Traumeel® work with the body’s natural resources to
  • Reduce pain after injury
  • Reduce swelling & bruising
  • Relief joint & muscle pain
  • Promote healing without masking injury
  • Provide immune support
  • Reduce recovery time
  • Treat minor bleeding 
Ultra Protein Plus  is a delicious vanilla bean flavored protein drink. It is nutritionally fortified with all the  indispensable amino acids essential to health, along with a full spectrum of vitamins & minerals.
BeneGene a powerful Anti-Aging & antioxidant supplement. The main ingredients in benaGene are Vitamin C & Oxaloacetate, natural compounds found in every cell of your body.
5-MTHF, L-methylfolate is the form of folic acid best utilized by the body and the only form of folic acid that crosses the blood brain barrier, where it is utilized for serotonin, dopamine, and norepinephrine metabolism. 
You can find all of the other doctor selected products we offer on our new use to navigate alphabetical list

About Dr. Slagle
Priscilla Slagle, M.D. is in the private practice of Nutritional and Functional Medicine & Psychiatry in Palm Springs, California.
Dr. Slagle has incorporated vitamins, minerals, amino acids, herbs, natural hormones & other natural substances into her practice since 1975, being one of the pioneers in the Alternative Medicine Field. She also incorporates hypnosis, EFT, and other reprogramming techniques.
Her book "The Way Up From Down" presents her natural "precursor" methods for lifting low moods & relieving the negative effects of stress.