The Way Up
Do we all dance to the beat of a Different Drummer Who happens to be the same? The Way Up Newsletter
Vol 4
  Already the year is flying by! 
I hope you are all off to the creation of new dreams & REALITIES.

Last month I had the stimulation & pleasure of attending the 6th International Congress on Anti-Aging & Bio-Medical Technologies sponsored by the American Academy of Anti-Aging Medicine.

It was fascinating to better understand the process of cloning & to hear from a brilliant man who intends to be the first to clone himself.  He has set up a research center to study cloning as an alternative for infertile couples. Provocative stuff but let's get on to what you can use & some of what I found most interesting.

Will give enough scientific detail to make it understandable, but I hope not tedious & boring.  (Let me know on our feedback bar how heavy or lightweight you want the news to be)

So without further ado:


In l998 84,500 new cases were diagnosed in the U.S.  The current consensus is that men over 40 years old should have a yearly blood test for total PSA (prostate specific antigen).  A level of 0-4 is normal;  4-10 is ambiguous (may or may not suggest cancer as can be elevated by infection, inflammation, & benign prostatic hypertrophy): over 10 may often suggest cancer.

Those with a PSA over 4 should then have a Free PSA blood test.  This helps differentiate who needs a prostate biopsy.  Those with Free PSA levels greater than 25% need a biopsy & have a higher risk of cancer.  This test helps avoid unneeded biopsies.


Recent studies suggest that specific by products of the estrogens, estradiol & estrone may be responsible for both breast & prostate cancers.  These culprits are called 4-catechol estrogens & estrogen 3,4-quinone.

Yes, men have estrogen too.  An unwanted chemical called aromatase helps to convert testosterone to estradiol.  Aromatase increases with aging, alcohol, obesity, & deficiencies of vitamin C, zinc & phytochemicals (soy, high-lignan flaxseed oil, black cohosh, Dong quai, licorice root, & panax ginseng) & excess testosterone replacement.  You may have noticed men with increased breast size if they are obese or drink too much alcohol.  This is related to the increased estrogen production.

Alcohol plus estrogen replacement therapy & birth control pills taken by very young women are associated with an increased risk of breast cancer.  A decrease in melatonin, thyroid, progesterone & sex hormone binding globulins will increase breast & prostate cancer risk.

Now this is not to freak you out about estrogen or hormone replacement in menopause.  There is a practical useful side to this information.

Remember it is not the estrogen but the unwanted breakdown products that can be made from certain forms of estrogen that cause the problem.  If enough vitamin B12 & folic acid are present the 4-catechol estrogens will be methylated & safely excreted.  Otherwise pollutants ( & here is one place where the pollution connection comes in) converts the 4-catechol estrogens to estrogen 3,4 quinone (the other bad one).  This then can lead to DNA binding, mutations, & cancer.

There is more you can do because the amino acid, cysteine, antioxidants, vitamin E, selenium, zinc, garlic, Vitamin B12, folic acid & the previously mentioned phytochemicals help to either stop the formation of these dangerous metabolites or interfere with their negative impact on DNA.

Natural Progesterone is another help.  Many of the steps leading to estrogen- mediated cancer initiation, promotion & progression are impeded by natural progesterone. Because progesterone plays a role in preventing estrogen from converting to 4-catechol estrogens, it plays a role in protecting against both breast & prostate cancer.  Progesterone has anti-estrogen actions, increases the elimination of estrogen from the body & down regulates estrogen receptors.

In studies comparing the application to the breasts of progesterone cream vs placebo or estrogen cream.  The cells in the progesterone treated breasts had less cell division activity ( hence less stimulation & possible cancer risk). The dose was 1/4 tsp of progesterone cream equivalent to 30mg-the same dosage as in most of the progesterone creams in health food stores.  The estrogen cream used in the studies increased the rate of cell proliferation in the breast.  Also, applying progesterone cream helps to improve fibrocystic breasts.  The synthetic progesterone such as provera which is given to most women & is in birth control pills does not have these beneficial actions.

There is more good news.  The potentially problematic estrogens are the estrone & estradiol, also known as E1 & E2.  There is an E3 called Estriol.  It does not convert to the 4-catechol estrogens associated with increased cancer risk.  Estriol is the primary form of estrogen used by Drs who practice alter- natively & is available from compounding pharmacies.  It is usually combined with lesser amounts of estradiol or both estradiol & estrone & is known as Biestrogen or Triestrogen.  Women who inherently have higher levels of estriol have a lower risk of breast cancer.  Some compounding pharmacies are listed in out links.

You'll be able to learn more details if you've survived this & are game for more by reading the soon to be released book by David Zava PhD on the origins of breast & prostate cancer, the exact title which is not yet available.  He is the cancer researcher who presented this information at the meeting.

So there are many things we can do to protect ourselves from these relatively common cancers as we go through life & if you've gotten this far through this newsletter you are likely proactive in gaining & securing good health.

You can read more about any of the items mentioned by going to  Though I could go on & on, you've probably had enough for now. Please give feedback on what you want to hear about. 

Feel free to forward to anyone you think would be interested & may you be blessed.

Allowing always the newness, releasing
Moving, spiraling to new heights of
Universal Participation

Until next time     
Priscilla Slagle M.D.
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